Detalhe da pesquisa
1.
The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity.
Nature
; 575(7781): 217-223, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31666701
2.
Use of a small molecule cell cycle inhibitor to control cell growth and improve specific productivity and product quality of recombinant proteins in CHO cell cultures.
Biotechnol Bioeng
; 112(1): 141-55, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25042542
3.
IgG1 thioether bond formation in vivo.
J Biol Chem
; 288(23): 16371-16382, 2013 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-23625924
4.
Phosphoinositide-3-kinase inhibitors: evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511.
Bioorg Med Chem Lett
; 24(24): 5630-5634, 2014 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25466188
5.
Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers.
Nat Cancer
; 5(1): 66-84, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38151625
6.
Discovery of 2-methylpyridine-based biaryl amides as γ-secretase modulators for the treatment of Alzheimer's disease.
Bioorg Med Chem Lett
; 23(23): 6447-54, 2013 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24139583
7.
Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors.
Biochim Biophys Acta
; 1814(12): 1947-54, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21835273
8.
Synthesis and structure-activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold.
Bioorg Med Chem Lett
; 22(17): 5714-20, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22832322
9.
Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe.
J Med Chem
; 65(6): 4972-4990, 2022 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35286090
10.
Structural, mechanistic, and computational analysis of the effects of anomeric fluorines on anomeric fluoride departure in 5-fluoroxylosyl fluorides.
J Am Chem Soc
; 133(40): 15826-9, 2011 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-21910446
11.
Development of a High-Throughput Affinity Mass Spectrometry (AMS) Platform Using Laser Diode Thermal Desorption Ionization Coupled to Mass Spectrometry (LDTD-MS).
SLAS Discov
; 26(2): 230-241, 2021 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-33334237
12.
Systematic Study of the Glutathione Reactivity of N-Phenylacrylamides: 2. Effects of Acrylamide Substitution.
J Med Chem
; 63(20): 11602-11614, 2020 10 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32965113
13.
Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors.
J Med Chem
; 63(1): 52-65, 2020 01 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31820981
14.
High-throughput assays for sirtuin enzymes: a microfluidic mobility shift assay and a bioluminescence assay.
Anal Biochem
; 378(1): 53-9, 2008 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18358225
15.
A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation.
J Med Chem
; 61(2): 453-461, 2018 01 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28378579
16.
Discovery of acetyl-coenzyme A carboxylase 2 inhibitors: comparison of a fluorescence intensity-based phosphate assay and a fluorescence polarization-based ADP Assay for high-throughput screening.
Assay Drug Dev Technol
; 5(2): 225-35, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17477831
17.
A high-throughput microfluidic assay for SH2 domain-containing inositol 5-phosphatase 2.
Assay Drug Dev Technol
; 4(2): 175-83, 2006 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-16712421
18.
High-Throughput Mass Spectrometric Analysis of Covalent Protein-Inhibitor Adducts for the Discovery of Irreversible Inhibitors: A Complete Workflow.
J Biomol Screen
; 21(2): 136-44, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26676098
19.
Facile Modulation of Antibody Fucosylation with Small Molecule Fucostatin Inhibitors and Cocrystal Structure with GDP-Mannose 4,6-Dehydratase.
ACS Chem Biol
; 11(10): 2734-2743, 2016 10 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-27434622
20.
Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease.
J Med Chem
; 58(1): 480-511, 2015 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-25469863